Nucleotide sequence of a full-length cDNA for arylamine N-acetyltransferase from rabbit liver

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Nucleotide sequence of a full-length cDNA for arylamine N-acetyltransferase from rabbit liver.

A full-length cDNA clone encoding rabbit liver arylamine *• N-acetyltransferase (NAT; EC 2.3.1.5) was isolated from a Xgtll [ expression library by concomitant screening with an oligonucleof tide deduced from partial amino acid sequences (1) and with antibodies raised against the purified protein. The nucleotide p sequence of the clone, designated rnat, consists of 1102 nucleotides and contains...

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Arylamine N-acetyltransferase.

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Molecular and genetic analyses of arylamine N-acetyltransferase polymorphism of rabbit liver.

A cDNA clone encoding the full coding region of polymorphic arylamine N-acetyltransferase was isolated from rabbit liver and expressed in Chinese hamster ovary cells. The expressed enzyme acetylated 2-aminofluorene, procainamide, sulfamethazine, and p-aminobenzoic acid at equivalent rates. N-Acetyltransferase activity was measured in 17 rabbits from an inbred colony which were classified into r...

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ژورنال

عنوان ژورنال: Nucleic Acids Research

سال: 1989

ISSN: 0305-1048,1362-4962

DOI: 10.1093/nar/17.9.3589